PumptheIron – Body Building Blog

Pro Hormones

Nomenclature/Chemical naming info:

For reference:

etioallocholan = 5a-androst = ‘a skeleton’ or ‘a isomer’

etiocholan = 5b-androst = ‘b skeleton’ or ‘b isomer’

17beta-hydroxy = 17b-ol

estra = 19-norandrost

1-AD (1-androstenedione) 1-androstene-3b,17b-dione or androst-1-ene-3b,17b-dione

1-AD (1-androstenediol) 1-androstene-3b,17b-diol or androst-1-ene-3b,17b-diol

4-AD (4-androstenedione) 4-androstene-3b,17b-dione or androst-4-ene-3b,17b-dione

4-AD (4-androstenediol) 4-androstene-3b,17b-diol or androst-4-ene-3b,17b-diol

1,4AD (Boldione) 1,4-androstadiene-3b,17b-dione or androst-1,4-diene-3b,17b-dione

M1,4AD (Dianadiol) 17a-methyl-1,4-androstadiene-3b,17b-diol or 17a-methyl-androst-1,4-diene-3b,17b-diol

19-Tren X (Pro-Dienolone) 19-norandrosta-4,9-diene-3b,17b-dione or estra-4,9-diene-3b,17b-dione

Max LMG 13-ethyl-3-methoxy-gona-2,5(10)-diene-17-one

Orastan-A (Furazabol THP) 5a-androstano[2,3-c]furazan-17b-tetrahydropyranol ether

Orastan-E (Stanozol THP) [3,2-c]pyrazole-5alpha-etioallocholane-17b-tetrahydropyranol

Halodrol-50 (Turinadiol) 4-chloro-17a-methyl-androst-1,4-diene-3b,17b-diol

Promagnon-25 (Methyl-Clostediol) 4-chloro-17a-methyl-androst-4-ene-3b,17b-diol

Propadrol 12-ethyl-3-methoxy-gona-diene-17 6-17 dihydroxyetiocholove-3-ol proponate

11-OXO (Adrenosterone) 4-androstene-3,11,17-trione or 11-oxo-androstenedione

Methoxy-TRN 17b-methoxy-trienbolone

Methoxy-TST 17b-methoxy-trienosterone

19-Nor (19-norandrostenediol) 19-nor-4-androsten-3b,17b-diol or 19-norandrost-4-ene-3b,17b-diol

5AA (5-alpha-androstanediol) 5a-androstane-3b,17b-diol

M5AA (Mestanolone) 17a-methyl-5a-androstanediol

3-Alpha (3-alpha-androstanediol) 5a-androstane-3alpha,17b-diol

M1T (Methyl 1-Test aka 17aa-1-testosterone) 17a-methyl-1-androstene-3-one-17b-ol or 17a-methyl-5a-androst-1-ene-3-one-17b-ol

Superdrol (Methyldrostanolone) 2a,17a-dimethyl-5a-androst-3-one-17b-ol or 2a,17a-dimethyl-etiocholan-3-one-17b-ol

Pheraplex (Madol or DMT) 17a-methyl-etioallocholan-2-ene-17b-ol or 17a-methyl-5a-androst-2-ene-17b-ol

Ergomax LMG (Ergo Matrix) 17a-methyl-delta-2-etioallocholane

Epithio (Havoc or Epistane) 2a,3a-epithio-17a-methyl-5a-androstan-17b-ol or 2a,3a-epithio-17a-methyl-etioallocholan-17b-ol

Methyl-D (Methyl Dienolone) 17a-methyl-19-Norandrosta-4,9(10)-diene-3-one-17b-ol or 17a-methyl-17b-hydroxy-estra-4,9(10)-diene-3-one

M4OHN (Methylhydroxynandrolone) 17a-methyl-4-hydroxy-19-norandrost-4-ene-3-one or 17a-methyl-4-hydroxy-estra-4-ene-3-one

4OHT (hydroxytestosterone) 4-hydroxy-androst-4-ene-3-one-17b-ol or 4,17-dihydroxy-androst-4-ene-3-one

MDHT (methyl-DHT/mestanolone) 17a-methyl-5a-androstane-3-one

• Prohormone Chart 1
  
• Prohormone Chart 2
  
• Prohormone Chart 3
• Prohormone Chart 4
• Prohormone Chart 5

    According to Wikipedia, "Steroidogenesis is the process wherein desired forms of steroids are generated by transformation of other steroids. The pathways of steroidogenesis can differ from organism to organism, but the pathways of human steroidogenesis are shown in the figure". Products of steroidogenesis include:

• Androgens
• Testosterone
• Estrogens and progesterone
• Corticoids
• Cortisol
• Aldosterone

 I think this is a useful reference chart from Wikipeida to pathways of formation of testosterone from cholesterol, or if you are taking a pro hormone, for example the original 1-AD (1-androstenedione), you can locate it in the chart and see how close it is to testosterone and its pathway. You can also see how estrogens are also formed from testosterone precursors as well as testosterone. No wonder the original 1-AD was so beloved by bodybuilders when it was on the market; it is one step away from conversion to testosterone! Dually note that it converts to estrone then estrodiol as well….thats not so good. Some conversion is necessary but to much is bad and will result in side effects such as gynocomastia. Remember a previous article that I posted (from Muscular Development) on the necessity of the presence of cholesterol for testosterone increases and protein synthesis! Hence you need cholesterol to build muscle, and the no or low cholesterol diets are not in the best interest of anabolism.

• Cholesterol Steroidogenesis Chart

  Below is information such as estimated half life and A:A ratio’s on certain compounds. I’ll update more as I find further info as much of it is compiled from original manufacturer claims and as such this should be used for reference purposes only. If anyone sees anything they can add or change please let me know. Anabolic to Androgenic ratio’s based on original manufacture claims and Vida info. Note many other unseen factors come into play that aren’t apparent in the ratio’s such as progesterone activity, and how ‘strongly’ a compound binds to the androgen receptors. For example Masteron has a relatively low A:A ratio and a pretty low androgenic # of about 25 but it binds very strongly and/or with high affinity compared to other compounds. Q-Factor is the anabolic # divided by androgenic #. Some anabolics are listed with a ‘range’ for the most accurate possible estimate. Methyl Testosterone is the oral of which all other orals are compared, just as IM Test is to other injectibles: 

• Prohormone Oral Availability Chart
  
• Steroid Pharmocology Chart 1
• Steroid Pharmocology Chart 2
• Steroid Pharmocology Chart 3

An article out of August’s issue of Muscular Development by steroid legal expert & lawyer Rick Collins, pertaining to the Department of Justice and DEA expounding on the legal definition of determining what & how substances meet the criteria to be included in the banned substances included under the Anabolic Steroid Control Act of 2004.

The particular chemicals that were left out of the Steroid Control Act of 2004 that are to be banned are:

• Boldione (1,4 androstadienedione)
  

• Desoxymethyltestosterone (Madol or DMT)
  

• 19-nor-4,9(10)-androstadienedione (aka) Estra-4,9-dien-3,17-dione

Boldione is also known by the following chemical name: androsta- 1,4-diene-3,17-dione. DEA has determined that the chemical structure of boldione is chemically related to that of testosterone. The chemical structure of boldione differs from testosterone by only the following two chemical groups: A ketone group at carbon 17 and a double bond between the first and second carbon. The human body would be expected to metabolize the ketone group at carbon 17 into a hydroxyl group that is present on testosterone. Furthermore, the scientific literature reports that the additional double bond at carbon 1 in boldione does not significantly decrease the anabolic activity of the substance (Vida, 1969). Boldione is an anabolic steroid precursor, being metabolized by the body into boldenone (Galletti and Gardi, 1971), which is a schedule III anabolic steroid (21 U.S.C. 801(41)(A)(vi)).

Desoxymethyltestosterone (DMT) is also known by the following names: 17[alpha]-methyl-5a-androst-2-en-17[beta]-ol; and madol. DEA has determined that the chemical structure of desoxymethyltestosterone is chemically related to testosterone. The chemical structure of desoxymethyltestosterone differs from testosterone by the following four chemical features: The lack of a ketone group at the third carbon, a double bond between the second and third carbon, the lack of a double bond between the fourth and fifth carbon, and a methyl group at carbon 17. Each of these four chemical features is known through the scientific literature not to eliminate the anabolic and androgenic activity of the substance (Brueggemeir et al., 2002; Vida, 1969).

19-Nor-4,9(10)-androstadienedione is also known by the following chemical names: 19-norandrostadiene-3,17-dione 4,9(10)-; and estra- 4,9(10)-diene-3,17-dione. DEA has determined that the chemical structure of 19-nor-4,9(10)-androstadienedione is chemically related to testosterone. The chemical structure of 19-nor-4,9(10)- androstadienedione differs from testosterone by the following three chemical groups: A ketone group at carbon 17, the absence of a methyl group at carbon 19, and a double-bond between the ninth and tenth carbon. The human body metabolizes the ketone group at carbon 17 into a hydroxyl group that is present on testosterone. Furthermore, the scientific literature reports that both the absence of the methyl group at carbon 19 and the additional double bond in 19-nor-4,9(10)- androstadienedione increase the anabolic activity of the substance (Vida, 1969).

The article states that the DEA may also be moving more quickly to classify additional substances as well.

Click on image to read article then click again to enlarge: