PumptheIron – Body Building Blog

Nebido is an injectable steroid that contains testosterone undecanoate, a very slow acting ester of testosterone. Nebido is being marketed as a replacement for established injectable testosterone products like Depo-Testosterone (Cypionate), Delatestryl (Enanthate), & Sustanon (a blend of Testosterone Propionate, Phenylpropionate, Isocaproate, & Decanoate ).

Testosterone Undecanoate is a modified form of testosterone, where a undecanoic acid ester has been attached. Esterified forms of testosterone are less polar than free testosterone, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free, active testosterone. Esterified forms of testosterone are designed to prolong the window of effect following administration, allowing for a less frequent injection schedule compared to injections of free, unesterified steroids. Nebido is designed to maintain physiological levels of testosterone for up to 14 weeks after injection. The half life of Testosterone Cypionate & Testosterone Enanthate is approximately 8 days after injection, requiring a more frequent injection schedule and less stable blood hormone levels than Nebido potentially offers.

As far as being a prescribed medication like Testosterone Cypionate and Enanthate, Nebido has yet to be cleared by the FDA, although it is already currently being prescribed in 86 foreign countries.

Muscular Development Magazine writer William Llewellyn published an article in the March 2010 issue on Nebido and its current FDA bid for acceptance. Click on the links below to read the article.

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References

Llewellyn, William. Anabolics. 9th ed. Jupiter, FL: Molecular Nutrition, 2009.

Llewellyn, William. “U.S. Aveed/Nebido Delayed.” Muscular Development Magazine Mar. 2010: 299-300. Print.

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Here is a short article posted by MuscularDevelopment -the most hardcore bodybuilding magazine- in which Robbie Durand MA, writes about cholesterol’s direct relationship to muscle building.

In short, cholesterol is needed for testosterone production. An increase in testosterone results in a rise in anabolism. That is why eggs have always been a staple of a bodybuilder’s diet. Click here to view a steroidogenesis chart diagramming cholesterol’s direct chemical pathway relationship to testosterone production. Notice that cholesterol is the base for all of the hormones produced in the chart.

Many people are afraid to eat large amounts of eggs in the quantity that bodybuilders are known to, for fear of heart related health risks. For anyone subscribing to that train of thought, I challenge you to read a previous article titled: Cholesterol- Key Role in Muscle Mass Increases- Don’t Be Afraid of The Egg!!

Another post that emphasizes the nutritional value of eggs can be read here and is titled: What Is Being In a State of Positive Nitrogen Balance? What Are Amino Acids? What Is Complete Protein? Learn About Protein Utilization (Chart) & Relationship To Food

As you read the above listed post, it is important to note that eggs are such a good source of quality protein that they are used as a basis of comparison in rating the protein quality of other foods, with eggs given an arbitrary value of a perfect 100. Eggs contain only 12% protein by weight. Yet because of the specific balance of amino acids present in that protein, 94% of it can be used by your body. Eggs are ultimately the most absorbable food source.

Here is the following article by Robbie Durand titled: Dietary Cholesterol Increases Muscle Mass.

“Many of the bodybuilders of the ‘60s who wanted to put on mass were on the Vince Gironda diet of steak, eggs and protein powder mixed with whole cream. The diet also recommended 36 whole eggs per day and 1-2 pounds of red meat per day. It was a high-fat, high-protein, low-carb diet, with plenty of green veggies. It was also packed with a lot of cholesterol, which may have been the most important component of the diet. Based on the last several articles that I have written, it should be no surprise that cholesterol is important for building muscle. Cholesterol is a precursor for testosterone production. Unlike most cells that use cholesterol primarily for normal cell functioning, Leydig cells (testosterone-producing cells in the testis) have additional requirements for cholesterol, because it is the essential precursor for testosterone production. A new study in Endocrinology sheds some interesting new evidence to support how cholesterol is needed for testosterone production. Researchers reported that an increase in leutinizing hormone (a hormone that signals testosterone production) resulted in an increase in the synthesis of cholesterol synthesis and uptake in the testis.16 So if you are on a low-cholesterol diet, it may have a negative impact on muscle building due to impaired androgen production. Researchers have long thought that cholesterol may be important for muscle building, but never had the science to back it up…until now.

A recent study put the cholesterol muscle building theory to the test. They took 25 men and 30 women who filled out food diaries of what they ate and followed them over 12 weeks in conjunction with a resistance training program. The researchers compared the relationship between dietary cholesterol and gains in muscle mass. At the end of the study, the average dietary cholesterol consumption was strongly associated with the change in lean mass. Interestingly enough, although dietary protein was correlated with dietary cholesterol, protein by itself was not significantly correlated with change in lean mass. This means the researchers found that cholesterol— but not protein— was associated with changes in lean muscle mass. This means that all those cholesterol-free Egg Beaters that bodybuilders have been eating for years aren’t going to do jack for building muscle! The researchers noted that the study participants with higher cholesterol levels were more likely to have higher levels of inflammatory chemicals and cardiovascular disease risk factors. The scientists noted that cholesterol increases the body’s inflammatory response to the muscle damage from exercise and that this inflammation response stimulates the body’s muscle-building “anabolic” processes. “While chronic inflammation in arteries or other tissues is unhealthful, short-lived inflammation is an integral part of the muscle-building process.”

1.    Riechman SE, Andrews RD, Maclean DA, Sheather S. Statins and dietary and serum cholesterol are associated with increased lean mass following resistance training. J Gerontol A Biol Sci Med Sci, 2007 Oct;62(10):1164-71.

Interesting article courtesy of Muscular Development concerning the uses for Testosterone Undecanoate (TU) & Norandrostenedione (Durabolin)